2. Make Sure Your Personal/Home Affairs are Sorted Out
Will you be leaving a pet at home who needs to be checked on every day? Do you need a friend, relative, or neighbor to collect your mail while you're away? Does your bank or credit card company know you'll be traveling and using your card in another state/city? Are you as caught up on work, or can you work ahead so that things will go more smoothly while you're unreachable?
These (and likely others) are all matters that need to be sorted out before you leave town.